{"created":"2023-07-25T09:58:41.666542+00:00","id":1336,"links":{},"metadata":{"_buckets":{"deposit":"55adb3ae-098c-40fa-be4c-38d4d406b2ee"},"_deposit":{"created_by":4,"id":"1336","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"1336"},"status":"published"},"_oai":{"id":"oai:nfu.repo.nii.ac.jp:00001336","sets":["6:100"]},"author_link":["2726","2724"],"item_1_alternative_title_5":{"attribute_name":"論文名よみ","attribute_value_mlt":[{"subitem_alternative_title":"チュウスウ　ノルアドレナリン　トウシャケイ　ノ　カレイ　ヘンカ　ト　カソセイ"}]},"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-03-30","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"23","bibliographicPageStart":"17","bibliographicVolumeNumber":"8","bibliographic_titles":[{"bibliographic_title":"日本福祉大学情報社会科学論集"},{"bibliographic_title":"Journal of social and information sciences, Nihon Fukushi University","bibliographic_titleLang":"en"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"城川, 哲也"},{"creatorName":"シロカワ, テツヤ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"2724","nameIdentifierScheme":"WEKO"}]}]},"item_1_creator_8":{"attribute_name":"著者名(英)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shirokawa, Testuya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2726","nameIdentifierScheme":"WEKO"}]}]},"item_1_description_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"The locus coeruleus (LC), located within the caudal pontine central gray, is composed of noradrenalinecontaining neurons. The axons of these neurons form extensive collateral branches that project widely to many brain sites. The function of the LC is still unclear at present, however, LC neurons are known that exhibit marked axonal regeneration and sprouting in response to brain damage. We investigated the agerelated changes in noradrenergic innervations of the frontal cortex, using in vivo electrophysiological techniques and immunohistochemistry. While noradrenergic innervations gradually decreased with age in the frontal cortex, a high degree of sprouting occurred in the LC axon terminals in the middle age. These findings suggested that the LC neurons preserve a strong capacity to remodel their axon terminals even in the aging brain. Exogenous brainderived neurotrophic factor (BDNF) infusion caused a marked increase in the density of noradrenergic axon in the aged brain, but no trophic action of BDNF was observed in the young and middle-aged brain. The result suggests that BDNF is necessary for the maintenance of noradrenergic innervations in the aged brain.","subitem_description_type":"Other"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA11386572","subitem_source_identifier_type":"NCID"}]},"item_1_text_2":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_text_value":"解説論文"}]},"item_1_text_3":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Original"}]},"item_1_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"日本福祉大学情報社会科学部"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2005-03-30"}],"displaytype":"detail","filename":"jyouhou08-05shirokawa.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"jyouhou08-05shirokawa","url":"https://nfu.repo.nii.ac.jp/record/1336/files/jyouhou08-05shirokawa.pdf"},"version_id":"8a844d98-7097-4962-8c08-d888b3137a52"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"青斑核，加齢，可塑性，ノルアドレナリン，脳由来神経栄養因子","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"中枢ノルアドレナリン投射系の加齢変化と可塑性","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"中枢ノルアドレナリン投射系の加齢変化と可塑性"},{"subitem_title":"Plasticity of central noradrenergic projections during aging","subitem_title_language":"en"}]},"item_type_id":"1","owner":"4","path":["100"],"pubdate":{"attribute_name":"公開日","attribute_value":"2005-03-30"},"publish_date":"2005-03-30","publish_status":"0","recid":"1336","relation_version_is_last":true,"title":["中枢ノルアドレナリン投射系の加齢変化と可塑性"],"weko_creator_id":"4","weko_shared_id":4},"updated":"2023-07-25T10:32:32.256716+00:00"}