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中枢ノルアドレナリン投射系の加齢変化と可塑性
https://nfu.repo.nii.ac.jp/records/1336
https://nfu.repo.nii.ac.jp/records/13361a54e1c4-56c2-4d96-81d6-4e352d01f252
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
jyouhou08-05shirokawa (1.5 MB)
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| Item type | 紀要論文(ELS) / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2005-03-30 | |||||
| タイトル | ||||||
| タイトル | 中枢ノルアドレナリン投射系の加齢変化と可塑性 | |||||
| タイトル | ||||||
| タイトル | Plasticity of central noradrenergic projections during aging | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 青斑核，加齢，可塑性，ノルアドレナリン，脳由来神経栄養因子 | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 記事種別(日) | ||||||
| 値 | 解説論文 | |||||
| 記事種別(英) | ||||||
| 言語 | en | |||||
| 値 | Original | |||||
| 論文名よみ | ||||||
| その他のタイトル | チュウスウ ノルアドレナリン トウシャケイ ノ カレイ ヘンカ ト カソセイ | |||||
| 著者名(日) |
城川, 哲也
× 城川, 哲也 |
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| 著者名(英) |
Shirokawa, Testuya
× Shirokawa, Testuya |
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| 著者所属(日) | ||||||
| 値 | 日本福祉大学情報社会科学部 | |||||
| 抄録(英) | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The locus coeruleus (LC), located within the caudal pontine central gray, is composed of noradrenalinecontaining neurons. The axons of these neurons form extensive collateral branches that project widely to many brain sites. The function of the LC is still unclear at present, however, LC neurons are known that exhibit marked axonal regeneration and sprouting in response to brain damage. We investigated the agerelated changes in noradrenergic innervations of the frontal cortex, using in vivo electrophysiological techniques and immunohistochemistry. While noradrenergic innervations gradually decreased with age in the frontal cortex, a high degree of sprouting occurred in the LC axon terminals in the middle age. These findings suggested that the LC neurons preserve a strong capacity to remodel their axon terminals even in the aging brain. Exogenous brainderived neurotrophic factor (BDNF) infusion caused a marked increase in the density of noradrenergic axon in the aged brain, but no trophic action of BDNF was observed in the young and middle-aged brain. The result suggests that BDNF is necessary for the maintenance of noradrenergic innervations in the aged brain. | |||||
| 雑誌書誌ID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11386572 | |||||
| 書誌情報 |
日本福祉大学情報社会科学論集 en : Journal of social and information sciences, Nihon Fukushi University 巻 8, p. 17-23, 発行日 2005-03-30 |
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